MOTS-c (10mg)

MOTS-c is a 16-amino-acid peptide (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) classified as a mitochondrial-derived peptide: its sequence is encoded by a short open reading frame within the mitochondrial 12S rRNA gene. The research material is produced by solid-phase synthesis.

From an analytical standpoint, MOTS-c is a basic peptide (three arginines and a lysine) with two methionines and a tryptophan. Methionine is prone to oxidation (+16 Da per site), so careful storage and analysis by HPLC or LC-MS help distinguish the intact peptide from oxidized species. In the laboratory MOTS-c is used in in vitro cell-culture and biochemical assays. M-Rogue Research supplies it as a lyophilized powder in a 10mg vial, shipped from our California warehouse.

Chemical Specifications

Third-Party Testing & Verification

The current lot of MOTS-c 10mg (lot 2026-01) was analyzed by ILS Laboratories in San Diego, California. The certificate lists M Rogue Research as the client (“Tested for: M Rogue Research”).

Certificate COA-2026-CBCT1O (analysis date 10/17/2026) reports an HPLC peptide purity of 99.77% against a specification of ≥95.0%, a net peptide content of 10.72 mg, identity confirmed by HPLC retention-time comparison with a reference standard, and a fentanyl immunoassay screen (50 ng/mL cutoff) reported as not detected. Purity is calculated by reversed-phase HPLC area normalization at 214 nm, as the percentage of the target peptide relative to all peptide-related peaks.

This COA covers lot 2026-01 only. It reports HPLC data and does not include mass-spectrometry data. View the MOTS-c 10mg COA

Storage & Reconstitution Guidelines

MOTS-c 10mg is supplied as a lyophilized (freeze-dried) powder in a sealed vial. In this form the peptide is considerably more stable than in solution, but it is still sensitive to moisture, heat and light. On receipt, store the unopened vial at -20°C, protected from light, in a dry container. Short periods at room temperature during transit are normal for lyophilized material.

Before opening, allow the vial to reach room temperature (typically 15–30 minutes) so that atmospheric moisture does not condense on the cold powder. Reconstitute with a solvent appropriate to your assay, such as sterile water or a suitable buffer; some sequences dissolve more readily in a small volume of dilute acetic acid or DMSO before dilution. Add solvent slowly down the vial wall and swirl gently rather than shaking or vortexing.

Once in solution, divide the material into single-use aliquots to avoid repeated freeze-thaw cycles. Store aliquots at -20°C (or -80°C for longer periods) and keep solutions in use at 2–8°C for short periods only. Record the lot number, solvent, concentration and date on every aliquot. For a full walkthrough, see our guide on lyophilized peptide handling, reconstitution and storage.

Compliance Disclaimer

All compounds are intended strictly for laboratory and scientific research purposes only. Not for human or animal consumption. For research purposes only. Not for human consumption. 21+.

Documentation & Further Reading

• Certificates of Analysis page
• How to Read and Verify a Peptide COA
• Lyophilized Peptide Handling, Reconstitution, and Storage
• Overview of Common Research Peptides in In Vitro Science
• Frequently asked questions